Dimethylamine → HCID 12074949, 화합물

HRID 647501노트

반응식

HRID 647501 반응식
[CH2:1]([O:8][C:9]1[C:10]([CH2:15][N:16]2C(=O)C3=CC=CC=C3C2=O)=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CNC>O>[NH2:16][CH2:15][C:10]1[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=[CH:12][N:11]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 132175412-{[3-(Benzyloxy)pyridin-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 12074949HCID 12074949, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Heat 75 gm of 3-benzyloxy-2-phthalimidomethylpyridine under reflux for one hour in 550 ml of a 40% aqueous dimethylamine solution. Cool the resulting reaction mixture to room temperature, then dilute it with 550 ml water and extract with dichloromethane. Wash the dichloromethane extract with brine and dry over anhydrous sodium sulfate. Filter the dried reaction mixture and remove the solvent dichloromethane from the filtrate under reduced pressure, yielding 2-aminomethyl-3-phenylmethoxypyridine, BP 145°-155°/0.5 mm.

후처리

  1. temperatureCool
  2. customthe resulting reaction mixture to room temperature
  3. extractionextract with dichloromethane
  4. washWash the dichloromethane
  5. extractionextract with brine
  6. dry with materialdry over anhydrous sodium sulfate
  7. filtrationFilter
  8. customthe dried reaction mixture
  9. customremove the solvent dichloromethane from the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-6fa904c302dd48f986b7419cefb74d14
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04409226

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