Acetyl chloride → N-{[3-(Benzyloxy)pyridin-2-yl]methyl}acetamide

HRID 647502노트

반응식

HRID 647502 반응식
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH2:6][C:7]1[C:12]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1.C(N(CC)CC)C>O1CCCC1>[C:1]([NH:5][CH2:6][C:7]1[C:12]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 12074949HCID 12074949, 화합물

생성물 1

HCID 13217542N-{[3-(Benzyloxy)pyridin-2-yl]methyl}acetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Add dropwise with stirring a solution of 3.5 ml acetyl chloride in 50 ml THF (tetrahydrofuran) to a cooled solution of 10 gm of 2-aminomethyl-3-phenylmethoxypyridine and 7.1 ml triethylamine in 125 ml THF. Warm to room temperature and stir an additional hour. Remove triethylamine hydrochloride by filtration and evaporate the filtrate under reduced pressure. Recrystallize the residue from toluene to obtain 2-acetamidomethyl-3-(phenylmethoxy)pyridine, mp 94°-96°.

후처리

  1. additionAdd dropwise
  2. filtrationRemove triethylamine hydrochloride by filtration
  3. customevaporate the filtrate under reduced pressure
  4. customRecrystallize the residue from toluene

출처 및 근거

ORD 기록
ord-4d62df5a6a494273b10d5c5f62458d92
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04409226

반응 노트

불러오는 중…