Acetyl chloride → N-{[3-(2-Phenylethyl)pyridin-2-yl]methyl}acetamide

HRID 647504노트

반응식

HRID 647504 반응식
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH2:6][C:7]1[C:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1.C(N(CC)CC)C>C1COCC1>[C:1]([NH:5][CH2:6][C:7]1[C:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 20485150HCID 20485150, 화합물

생성물 1

HCID 20485147N-{[3-(2-Phenylethyl)pyridin-2-yl]methyl}acetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Add dropwise with stirring a solution of 1.24 gm acetyl chloride in 10 ml THF to a cooled solution of 3.2 gm of 2-aminomethyl-3-(2-phenylethyl)pyridine and 2.3 ml triethylamine in 100 ml THF. Warm the reaction mixture to room temperature and then stir for an additional 0.5 hour. Filter off the triethylamine hydrochloride and evaporate the filtrate under reduced pressure. Chromatograph on silica gel using 40% THF in chloroform to obtain 2-acetamidomethyl-3-(2-phenylethyl)pyridine.

후처리

  1. additionAdd dropwise
  2. filtrationFilter off the triethylamine hydrochloride
  3. customevaporate the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-79e05b060aae480e9679c512c85c0cac
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04409226

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