Peracetic Acid → (2-Ethyl-1,8-dioxaspiro[4.5]decan-2-yl)methanol

HRID 647747노트

반응식

HRID 647747 반응식
[CH2:1]=[C:2]([CH2:12][CH3:13])[CH2:3][CH2:4][C:5]1([OH:11])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.C(OO)(=[O:16])C>C(Cl)Cl>[CH2:12]([C:2]1([CH2:1][OH:16])[CH2:3][CH2:4][C:5]2([CH2:6][CH2:7][O:8][CH2:9][CH2:10]2)[O:11]1)[CH3:13]

참가 물질

4

반응물 2

HCID 6585Peracetic AcidHCID 132371754-(3-Methylidenepentyl)oxan-4-ol

생성물 1

HCID 13237164(2-Ethyl-1,8-dioxaspiro[4.5]decan-2-yl)methanol수율 69.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of 16.52 g of tetrahydro-4-(3-methylenepentyl)-2H-pyran-4-ol in 100 ml of methylene chloride under nitrogen was added portionwise 15.32 g of peracetic acid (with 0.40 g of anhydrous sodium acetate added). The reaction mixture was refluxed for 1 hour, allowed to set for 4 hours, diluted with 150 ml of methylene chloride, washed successively with water, twice with 25% potassium carbonate, and saturated sodium chloride, dried and filtered. The resulting solution was stripped to yield 12.42 g of the desired product as a pale yellow liquid.

후처리

  1. temperatureThe reaction mixture was refluxed for 1 hour
  2. washwashed successively with water, twice with 25% potassium carbonate, and saturated sodium chloride
  3. customdried
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-0fded67d8f374b2bb173593a462c50d1
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410354

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