Pyridine → Methyl N-[[[[[(diethoxyphosphinothioyl)propylamino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate

HRID 647789

반응식

HRID 647789 반응식
[CH3:1][NH:2][C:3]([O:5][N:6]=[C:7]([S:9][CH3:10])[CH3:8])=[O:4].[S:11](Cl)(Cl)=[O:12].C(N[P:19](=[S:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])CC.[N:27]1C=C[CH:30]=[CH:29][CH:28]=1>>[CH2:24]([O:23][P:19]([CH2:30][CH2:29][CH2:28][NH:27][S:11]([CH2:1][NH:2][C:3]([O:5][N:6]=[C:7]([S:9][CH3:10])[CH3:8])=[O:4])=[O:12])([O:20][CH2:21][CH3:22])=[S:26])[CH3:25]

참가 물질

5

반응물 4

HCID 1049PyridineHCID 4109MethomylHCID 24386Thionyl ChlorideHCID 2172696O,O-diethyl propylphosphoramidothioate

생성물 1

HCID 86739074Methyl N-[[[[[(diethoxyphosphinothioyl)propylamino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate

실험 절차

Methyl N-[[[[[(diethoxyphosphinothioyl)propylamino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate was prepared by the procedure employed in Example 9, by reacting methyl N-[[(methylamino)carbonyl]oxy]ethanimidothioate (2.43 g, 0.015 mole), thionyl chloride (1.79 g, 0.015 mole), and O,O-diethyl propylphosphoramidothioate (3.17 g, 0.015 mole) in pyridine (10 ml). Recrystallization from benzene-hexane afforded 3.87 g of colorless prisms of the formula below, mp 58~59°. ##STR26##

후처리

  1. customRecrystallization from benzene-hexane

출처 및 근거

ORD 기록
ord-9d82e983495342eb853bb716e11d862a
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410518

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