Cyclopropanecarbonyl chloride → 6-(p-cyclopropylcarbonylaminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

HRID 647803

반응식

HRID 647803 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[CH:16]1([C:19](Cl)=[O:20])[CH2:18][CH2:17]1>C1(C)C=CC=CC=1>[CH:16]1([C:19]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=3)=[CH:4][CH:3]=2)=[O:20])[CH2:18][CH2:17]1

참가 물질

4

반응물 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 161928Ici 109,081

생성물 1

HCID 128073316-(p-cyclopropylcarbonylaminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone수율 85%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

6.0 g (29.5 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone, 3.4 g (32.5 millimoles) of cyclopropanecarboxylic acid chloride and 100 ml of absolute toluene are kept for 6 hours at 80° C. The product is filtered off at 10° C., washed first with toluene and then with water, and recrystallized from dimethylformamide/water. 6.8 g (85% of theory) of 6-(p-cyclopropylcarbonylaminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone are obtained as beige crystals, of melting point 267°-268° C.

후처리

  1. filtrationThe product is filtered off at 10° C.
  2. washwashed first with toluene
  3. customwith water, and recrystallized from dimethylformamide/water

출처 및 근거

ORD 기록
ord-e693cae0b88e450eb731806d3818999c
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410529

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