Piperidine → 4-Ethyl-5-[4-(1-piperidinyl)benzoyl]-2-imidazolidinone

반응식

[CH2:1]([CH:3]1[NH:7][C:6](=[O:8])[NH:5][CH:4]1[C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13](F)=[CH:12][CH:11]=1)[CH3:2].[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH2:1]([CH:3]1[CH:4]([C:9](=[O:17])[C:10]2[CH:15]=[CH:14][C:13]([N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:12][CH:11]=2)[NH:5][C:6](=[O:8])[NH:7]1)[CH3:2]

참가 물질

반응물 2

HCID 8082Piperidine

HCID 204843625-Ethyl-4-(4-fluorobenzoyl)-2-imidazolidinone

생성물 1

HCID 204843634-Ethyl-5-[4-(1-piperidinyl)benzoyl]-2-imidazolidinone

실험 절차

A suspension of 10 g of 5-ethyl-4-(4-fluorobenzoyl)-2-imidazolidinone in 30 ml piperidine is stirred at reflux for 24 hours. Excess piperidine is evaporated under reduced pressure and the residue is purified by crystallization from alcohol.

후처리

temperatureat reflux for 24 hours
customExcess piperidine is evaporated under reduced pressure
customthe residue is purified by crystallization from alcohol

출처 및 근거

ORD 기록: ord-4ddbf90ac6ac4b019dcfaf4b60cee3f7
출처 데이터셋: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04410540

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