Carnitine Chloride → DL-Carnitine

HRID 64790

반응식

HRID 64790 반응식
[CH3:1][N+:2]([CH2:5][CH:6]([OH:11])[CH2:7][C:8]([OH:10])=[O:9])([CH3:4])[CH3:3].[Cl-]>O>[CH3:1][N+:2]([CH2:5][CH:6]([OH:11])[CH2:7][C:8]([O-:10])=[O:9])([CH3:3])[CH3:4]

참가 물질

3

반응물 1

HCID 5970Carnitine Chloride

생성물 1

HCID 288DL-Carnitine수율 97.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 35.0 g (0.177 mole) of DL-carnitine hydrochloride in 300 ml of water is passed through OH type strongly basic resin (Dowex-1X8) and the solution is concentrated to give 28.0 g (0.173 mole) of DL-carnitine. To DL-carnitine are added 61.9 g (0.173 mole) of dibenzoyl-L(+)tartaric acid and 90 ml of methanol. The mixture is dissolved under heat to form dibenzoyl-L(+)tartarates of D-carnitine and L-carnitine. The tartarates are cooled from 60° C. to 5° C. over a period of 24 hours to fractionally crystallize L-carnitine dibenzoyl-L(+)tartarate. The tartarate is filtered and washed to give L-carnitine dibenzoyl-L(+)tartarate (yield 39.0 g, purity 92.7%). The tartarate obtained is dissolved under heat in 190 ml of ethanol, and cooled from 60° C. to 25° C. over a period of 24 hours. This recrystallization gives 21.5 g of crystals of L-carnitine dibenzoyl-L(+)tartarate. [α]D25 =-96.2° (c= 1, MeOH), m.p. 154° C. (dec.), purity 99.7%.

후처리

  1. concentrationthe solution is concentrated

출처 및 근거

ORD 기록
ord-777d64ef8f9a4ebb9df81868da07dcf0
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610828

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