1-Sec-butyl-piperidin-4-one → 9-Sec.-butyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

HRID 647936노트

반응식

HRID 647936 반응식
Cl.[NH:2]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][CH:10]=[C:9]([CH3:12])[C:8]=2[CH:13]=1)N.[CH:14]([N:18]1[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1)([CH2:16][CH3:17])[CH3:15].C(O)(C)C.Cl>C(O)(C)C>[CH:14]([N:18]1[CH2:23][CH2:22][C:21]2[NH:2][C:4]3[C:13]([C:20]=2[CH2:19]1)=[C:8]1[C:9]([CH3:12])=[CH:10][S:11][C:7]1=[CH:6][CH:5]=3)([CH2:16][CH3:17])[CH3:15]

참가 물질

5

반응물 3

HCID 131828071-Sec-butyl-piperidin-4-oneHCID 204843225-Hydrazino-3-methylbenzothiophene hydrochlorideHCID 21912024Isopropanol hydrochloride

생성물 1

HCID 204842929-Sec.-butyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

11 g of 5-hydrazino-3-methylbenzothiophene hydrochloride and 8.5 g of 1-sec.-butyl-4-piperidone are boiled in 35 ml of isopropanol, and during this procedure isopropanol/HCl are added dropwise. The mixture is then evaporated, the residue is taken up in water and the mixture is rendered alkaline and extracted with methylene chloride. After washing and drying the organic phase, it is evaporated and the residue is recrystallised from cyclohexane. Melting point: 136°-137° C.

후처리

  1. customThe mixture is then evaporated
  2. extractionextracted with methylene chloride
  3. washAfter washing
  4. customdrying the organic phase, it
  5. customis evaporated
  6. customthe residue is recrystallised from cyclohexane

출처 및 근거

ORD 기록
ord-df7cf8c6b553416f8d8f5dedd3a353ab
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410536

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