3-Chloro-N,N-dimethyl-1-propanamine → 9-(3-Dimethylaminopropyl)-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

HRID 647944노트

반응식

HRID 647944 반응식
[CH3:1][C:2]1[C:6]2=[C:7]3[C:11](=[CH:12][CH:13]=[C:5]2[S:4][CH:3]=1)[NH:10][C:9]1[CH2:14][CH2:15][NH:16][CH2:17][C:8]3=1.[CH3:18][N:19]([CH3:24])[CH2:20][CH2:21][CH2:22]Cl>CN(C)C=O>[CH3:18][N:19]([CH3:24])[CH2:20][CH2:21][CH2:22][N:16]1[CH2:15][CH2:14][C:9]2[NH:10][C:11]3[C:7]([C:8]=2[CH2:17]1)=[C:6]1[C:2]([CH3:1])=[CH:3][S:4][C:5]1=[CH:13][CH:12]=3

참가 물질

4

반응물 2

HCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 20484283HCID 20484283, 화합물

생성물 1

HCID 204843129-(3-Dimethylaminopropyl)-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

10 g of 1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole, dissolved in 200 ml of dimethylformamide at 90° C., are heated to 90° with a solution of 12 ml of 3-dimethylaminopropyl chloride in 50 ml of dimethylformamide for 3 hours. The reaction mixture is filtered, the filtrate is evaporated and the residue is taken up in chloroform. After washing with water and drying, the organic phase is concentrated, the residue is chromatographed on SiO2 with chloroform/methanol/NH4OH (7:3:0:1) and the product is recrystallised from isopropanol. Melting point: 184° C.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. washAfter washing with water
  4. customdrying
  5. concentrationthe organic phase is concentrated
  6. customthe residue is chromatographed on SiO2 with chloroform/methanol/NH4OH (7:3:0:1)
  7. customthe product is recrystallised from isopropanol

출처 및 근거

ORD 기록
ord-623cd7677ddf4e8fb8633c361bf4b97d
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410536

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