Thionyl Chloride → 2,3-Dichloro-5-(chloromethyl)pyridine

HRID 647973

반응식

[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([CH2:9]O)=[CH:4][N:3]=1.S(Cl)([Cl:13])=O>>[Cl:13][CH2:9][C:5]1[CH:6]=[C:7]([Cl:8])[C:2]([Cl:1])=[N:3][CH:4]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 21882961(5,6-Dichloropyridin-3-yl)methanol

생성물 1

HCID 101765362,3-Dichloro-5-(chloromethyl)pyridine

실험 절차

2,3-Dichloro-5-hydroxymethyl-pyridine is reacted in a known manner with thionyl chloride to give 5-chloromethyl-2,3-dichloro-pyridine and the latter is reacted with sodium cyanide, without additional purification (for example analogously to L. A. Carlson et al., Acta Pharm. Suecica 9, 411 (1972)). 5,6-Dichloro-pyridine-3-acetonitrile, thus obtained, melts at 72°-75° C. after recrystallisation from ether.

출처 및 근거

ORD 기록: ord-906e38de8aae4bf6b7dc561e614fb8f0
출처 데이터셋: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04410530

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