m-Chloroperbenzoic acid → 2-Methyl-5-[(oxiran-2-yl)methoxy]-1-oxo-1lambda~5~-pyridine

HRID 647991노트

반응식

HRID 647991 반응식
ClC1C=CC=C(C(OO)=[O:9])C=1.[O:12]1[CH2:23][CH:13]1[CH2:14][O:15][C:16]1[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=1>ClCCl>[O:12]1[CH2:23][CH:13]1[CH2:14][O:15][C:16]1[CH:17]=[N+:18]([O-:9])[C:19]([CH3:22])=[CH:20][CH:21]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 222202352-Methyl-5-[(oxiran-2-yl)methoxy]pyridine

생성물 1

HCID 204834682-Methyl-5-[(oxiran-2-yl)methoxy]-1-oxo-1lambda~5~-pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 12.2 g of m-chloroperbenzoic acid in 100 ml of dichloromethane is added dropwise over the course of approx. 10 minutes, whilst stirring, to a solution of 10 g of crude 3-(2,3-epoxy-propoxy)-6-methyl-pyridine in 100 ml of dichloromethane, the temperature of the solution rising to 32° C. The reaction mixture is stirred for a further 30 minutes and is then extracted with 40 ml of saturated potassium bicarbonate solution, dried and evaporated in vacuo. 3-(2,3-Epoxy-propoxy)-6-methylpyridine-1-oxide, thus obtained, is used further in the crude state.

후처리

  1. customrising to 32° C
  2. extractionis then extracted with 40 ml of saturated potassium bicarbonate solution
  3. customdried
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6f5730494ad14f3696081fa3d4a94d19
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04410530

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