3-Hydroxybenzaldehyde → 3-(3-Chloro-2-hydroxypropoxy)benzaldehyde

HRID 648181노트

반응식

HRID 648181 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH2:10]([CH:12]1[O:14][CH2:13]1)[Cl:11]>N1C=CC=CC=1>[Cl:11][CH2:10][CH:12]([OH:14])[CH2:13][O:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6]

참가 물질

4

반응물 2

HCID 1013-HydroxybenzaldehydeHCID 7835Epichlorohydrin

생성물 1

HCID 128784723-(3-Chloro-2-hydroxypropoxy)benzaldehyde

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 3-hydroxybenzaldehyde (24.4 g, 0.2 mol), epichlorohydrin (47 ml) and pyridine (0.4 ml) is heated 5 hours on a steam bath. The crude mixture is partitioned between methylenechloride-water and the CH2Cl2 extract washed with dilute aqueous NaHCO3, dried (Na2SO4), filtered and concentrated in vacuo to give the crude title product. Distillation gives a colorless oil bp 160° (0.2 mm); 21.2 g.

후처리

  1. temperatureis heated 5 hours on a steam bath
  2. customThe crude mixture is partitioned between methylenechloride-water
  3. extractionthe CH2Cl2 extract
  4. washwashed with dilute aqueous NaHCO3
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customto give the crude title product
  9. distillationDistillation

출처 및 근거

ORD 기록
ord-228ebbddc8eb438a96c0fc17d988e7ed
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04411899

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