Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Chloro-2-fluorobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 반응물 | 4-Chloro-2-fluorotoluene | HCID 520630 | — |
| 생성물 | 4-Chloro-2-fluorobenzoic acid | HCID 99152 | — |
반응 단계
A mixture of 2-fluoro-4-chlorotoluene (25.05 g), KMnO4 (55.04 g) and water (400 ml) is heated to reflux for about 5 hr. The reaction is then worked up by filtering while hot through Celite and the filtrate is acidified with 2 N HCl. White crystals are filtered off, dissolved in ether and washed with water and brine, dried over sodium sulfate, filtered and evaporated to yield 2-fluoro-4-chlorobenzoic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04411912 |
| 출처 데이터셋 | uspto-grants-1983_10 |
| ORD ID | ord-fe95aca8fcee4fd08b57c1ccc7c845a0 |
| 출처 메모 | uspto-grants-1983_10 |