Water → 4-Chloro-2-fluorobenzoic acid

HRID 648286

반응식

HRID 648286 반응식
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[O-:10][Mn](=O)(=O)=O.[K+].[OH2:16]>>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])=[O:16]

참가 물질

4

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 5206304-Chloro-2-fluorotoluene

생성물 1

HCID 991524-Chloro-2-fluorobenzoic acid

실험 절차

A mixture of 2-fluoro-4-chlorotoluene (25.05 g), KMnO4 (55.04 g) and water (400 ml) is heated to reflux for about 5 hr. The reaction is then worked up by filtering while hot through Celite and the filtrate is acidified with 2 N HCl. White crystals are filtered off, dissolved in ether and washed with water and brine, dried over sodium sulfate, filtered and evaporated to yield 2-fluoro-4-chlorobenzoic acid.

후처리

  1. temperatureis heated
  2. temperatureto reflux for about 5 hr
  3. filtrationby filtering while hot through Celite
  4. filtrationWhite crystals are filtered off
  5. dissolutiondissolved in ether
  6. washwashed with water and brine
  7. dry with materialdried over sodium sulfate
  8. filtrationfiltered
  9. customevaporated

출처 및 근거

ORD 기록
ord-fe95aca8fcee4fd08b57c1ccc7c845a0
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04411912

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