(S)-1-benzyloxycarbonyl-N-2-hydroxyethyl-2-pyrrolidinecarboxamide → (S)-N-(2-Hydroxyethyl)pyrrolidine-2-carboxamide

HRID 64832노트

반응식

HRID 64832 반응식
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16]([NH:18][CH2:19][CH2:20][OH:21])=[O:17])=O)C1C=CC=CC=1>CO.[C].[Pd]>[OH:21][CH2:20][CH2:19][NH:18][C:16]([C@@H:12]1[CH2:13][CH2:14][CH2:15][NH:11]1)=[O:17]

참가 물질

4

반응물 1

HCID 13564346(S)-1-benzyloxycarbonyl-N-2-hydroxyethyl-2-pyrrolidinecarboxamide

생성물 1

HCID 12136434(S)-N-(2-Hydroxyethyl)pyrrolidine-2-carboxamide수율 99.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

In 70 ml of methanol was dissolved 5.92 g of compound (79) and the compound was catalytically reduced by an ordinary method using 10% palladium-carbon as a catalyst. After the reaction, the catalyst and the solvent were removed to provide 3.2 g of syrupy (S)-N-2-hydroxyethyl-2-pyrrolidinecarboxamide (53). The product was solidified when it was refrigerated.

후처리

  1. customAfter the reaction
  2. customthe catalyst and the solvent were removed

출처 및 근거

ORD 기록
ord-78a0030d60754c27bf06653ff5cdac70
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610821

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