2-Aminopyrimidine → HCID 20144976, 화합물

HRID 648577노트

반응식

HRID 648577 반응식
Br.[NH2:2][C:3]1[S:4][C:5]([C:9](=O)[CH2:10]Br)=[C:6]([CH3:8])[N:7]=1.[NH2:13][C:14]1[N:19]=[CH:18][CH:17]=[CH:16][N:15]=1.C(N(CC)CC)C>C(O)C>[NH2:2][C:3]1[S:4][C:5]([C:9]2[N:13]=[C:14]3[N:19]=[CH:18][CH:17]=[CH:16][N:15]3[CH:10]=2)=[C:6]([CH3:8])[N:7]=1

참가 물질

5

반응물 3

HCID 79782-AminopyrimidineHCID 8471TriethylamineHCID 20145033HCID 20145033, 화합물

생성물 1

HCID 20144976HCID 20144976, 화합물수율 15.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-amino-4-methyl-5-(2-bromoacetyl)thiazole hydrobromide (7.2 g), 2-aminopyrimidine (3.8 g) and triethylamine (11 ml) in ethanol (200 ml) was refluxed for 8 hours and the reaction mixture was evaporated in vacuo. To the residue was added water and the resulting mixture was acidified to pH 1.0 with 10% hydrochloric acid. The acidified solution was treated with charcoal and filtered. The filtrate was adjusted to pH 7.0 with 20% aqueous potassium carbonate. The resulting precipitate was collected by filtration, washed successively with water and ethyl acetate, and recrystallized from aqueous ethanol to give 2-(2-amino-4-methyl-5-thiazolyl)imidazo[1,2-a]pyrimidine (0.8 g). mp 285°-286° C. (dec.).

후처리

  1. customthe reaction mixture was evaporated in vacuo
  2. additionTo the residue was added water
  3. additionThe acidified solution was treated with charcoal
  4. filtrationfiltered
  5. filtrationThe resulting precipitate was collected by filtration
  6. washwashed successively with water and ethyl acetate
  7. customrecrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-a8252c3de525453db558776aab892b79
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04735957

반응 노트

불러오는 중…