Water → 2-Nitro-6-piperidinobenzonitrile

HRID 64860

반응식

HRID 64860 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[C:5]=1[C:6]#[N:7])([O-])=O.N1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.O>CN(C)C=O>[N+:12]([C:8]1[CH:9]=[CH:10][CH:11]=[C:4]([N:1]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[C:5]=1[C:6]#[N:7])([O-:14])=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 8082PiperidineHCID 520718Dinitrobenzonitrile

생성물 1

HCID 127157822-Nitro-6-piperidinobenzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

실험 절차

5.8 g of 2,6-dinitrobenzonitrile was dissolved in 30 ml of dimethylformamide, and 10.2 ml of piperidine was added to the solution. The mixture was stirred at 50° C. for 30 minutes while externally cooling because of heat generation. The reaction mixture was poured into water, and the precipitate thus formed was collected, washed with water and then with methanol, and dried to obtain 6.7 of 2-nitro-6-piperidinobenzonitrile (melting point: 122°-123° C.).

후처리

  1. temperaturewhile externally cooling because of heat generation
  2. customthe precipitate thus formed
  3. customwas collected
  4. washwashed with water
  5. dry with materialwith methanol, and dried

출처 및 근거

ORD 기록
ord-8573d96496554b0985a0d4bbbd31d42b
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610987

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