Methyl Acrylate → Methyl 3-(phenylthio)propionate

HRID 648624노트

반응식

HRID 648624 반응식
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[C:15]([O:19][CH3:20])(=[O:18])[CH:16]=[CH2:17]>C(Cl)Cl>[C:1]1([S:7][CH2:17][CH2:16][C:15]([O:19][CH3:20])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 7294Methyl AcrylateHCID 7969ThiophenolHCID 8471Triethylamine

생성물 1

HCID 350367Methyl 3-(phenylthio)propionate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thiophenol (440 mg, 4 mmol) and Et3N (70 μl, 0.5 mmol) were dissolved in CH2Cl2 (5 ml). Methyl acrylate (412 mg, 4.8 mmol) was added dropwise. The reaction was exothermic. After stirring at room temperature for 30 minutes, the excess methyl acrylate was removed in vacuo. TLC: silica gel, Et2O-hexane 1:2, UV Rf =0.58. The crude title ester was used without further purification.

후처리

  1. customthe excess methyl acrylate was removed in vacuo
  2. customThe crude title ester was used without further purification

출처 및 근거

ORD 기록
ord-49eb8f9cfeef495d87447e5574807b06
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04735962

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