HCID 20145212, 화합물 → HCID 20145176, 화합물

HRID 648657노트

반응식

HRID 648657 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:6]([CH:8]([CH:12]([C:22]([NH2:24])=[O:23])[C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11])[CH:7]=1.[H][H]>C(O)C.[Pd]>[N:25]1([C:5]2[CH:4]=[CH:3][CH:2]=[CH:7][C:6]=2[CH:8]([CH:12]([C:22]([NH2:24])=[O:23])[C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1

참가 물질

5

반응물 2

HCID 20145212HCID 20145212, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20145176HCID 20145176, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

One gram (2.33 m mol) of 4-[(1-(5-chloro-2-piperidinophenyl)-1-butyl)-aminocarbonylmethyl]-benzoic acid in 40 ml of absolute ethanol was hydrogenated on 0.5 gm of 10% palladium/charcoal at 50° C. and under 5 bar of hydrogen. After two hours, the catalyst was filtered off over kieselguhr, and the filtrate was concentrated by evaporation in vacuo. The evaporation residue was distributed at pH 6 between water and ethyl acetate. The organic extract was washed with water, dried, filtered, and evaporated in vacuo.

후처리

  1. filtrationthe catalyst was filtered off over kieselguhr
  2. concentrationthe filtrate was concentrated by evaporation in vacuo
  3. extractionThe organic extract
  4. washwas washed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-520e625b59054f978c9441a6f29369ca
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04735959

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