Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 2-Chloro-4-(4-fluorobenzoyl)-pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 4-(4-fluorobenzoyl)-pyridine N-oxide | HCID 54143203 | — |
| 생성물 | 2-Chloro-4-(4-fluorobenzoyl)-pyridine | HCID 20145710 | — |
반응 단계
0.88 g 4-(4-fluorobenzoyl)-pyridine N-oxide and 50 ml POCl3 are refluxed for 2 hrs. Excess POCl3 is distilled at normal pressure. The crude is treated with slightly alkaline cold water and then extracted with methylene chloride. Working as usual affords 0.80 g of title product, identical with that obtained by the Friedel-Crafts process (see Ex. 3d).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04736037 |
| 출처 데이터셋 | uspto-grants-1988_04 |
| ORD ID | ord-297ae98322534e3db5a0a6253499a89f |
| 출처 메모 | uspto-grants-1988_04 |