Formaldehyde → 3-(Anilinomethyl)-1,3-benzothiazole-2(3H)-thione

HRID 648866노트

반응식

HRID 648866 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH:8][C:9]1[S:10][C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[N:13]=1.[CH2:18]=O>C(O)C>[C:2]1([NH:1][CH2:18][N:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[S:10][C:9]2=[S:8])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 6115AnilineHCID 178418395HCID 178418395, 화합물

생성물 1

HCID 2204713-(Anilinomethyl)-1,3-benzothiazole-2(3H)-thione

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

With stirring, 18.63 (0.2 mole) of aniline are added to a suspension of 33.45 g (0.2 mole) of 2-mercaptobenzothiazole in 120 ml of ethanol, the temperature rising to 30° C. Then 16.4 g (0.2 mole) of 37% aqueous formaldehyde solution are added and stirring is continued for 30 minutes. The precipitate is isolated by filtration and washed with cold ethanol and hexane, affording 47 g of 3-(phenylaminomethyl)benzothiazoline-2-thione which melts at 102°-103° C.

후처리

  1. customrising to 30° C
  2. stirringstirring
  3. customThe precipitate is isolated by filtration
  4. washwashed with cold ethanol and hexane

출처 및 근거

ORD 기록
ord-a25db00b12044a95b69e1837bc8cddc5
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737302

반응 노트

불러오는 중…