Water → Acetic acid, 2-(4-nitrophenyl)hydrazide

HRID 648899노트

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HRID 648899 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][NH2:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(N(CC)CC)C.[C:19](Cl)(=[O:21])[CH3:20].O>C(#N)C>[C:19]([NH:11][NH:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)(=[O:21])[CH3:20]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 3310889(4-Nitrophenyl)hydrazine

생성물 1

HCID 3404344Acetic acid, 2-(4-nitrophenyl)hydrazide수율 85.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
25 °C

실험 절차

In 100 ml of acetonitrile were dissolved 15.3 g of p-nitrophenylhydrazine and 10.1 g of triethylamine, and 7.9 g of acetyl chloride was added dropwise to the solution under ice-cooling over a period of 15 minutes. Thereafter, the mixture was stirred for 1 hour at 25° C., 100 ml of water was added therreto, and crystals thus deposited were collected by filtration and washed with acetonitrile to provide 16.6 g of 1-acetyl-2-(4-nitrophenyl)hydrazine. The melting point was 209°-214° C.

후처리

  1. additionwas added dropwise to the solution under ice-
  2. temperaturecooling over a period of 15 minutes
  3. filtrationthus deposited were collected by filtration
  4. washwashed with acetonitrile

출처 및 근거

ORD 기록
ord-15c10e3a5f594409860e99960babacdf
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737452

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