Sodium metaborate → 1-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol

HRID 64898

반응식

HRID 64898 반응식
B([O-])=O.[Na+].[CH2:5]([O:8][C:9]1[CH:27]=[CH:26][C:12]([O:13][CH:14]([N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)[C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:11][CH:10]=1)[CH:6]=[CH2:7]>CO>[CH2:5]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]([N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)[CH:15]([OH:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:26][CH:27]=1)[CH:6]=[CH2:7]

참가 물질

4

반응물 2

HCID 145326Sodium metaborateHCID 133686231-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone

생성물 1

HCID 133686241-(4-Allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol수율 97.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 g (0.027 mole) of sodium boranate is added in portions to 7.2 g (0.023 mole) of 1-(4-allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone (Example 1) in 80 ml of methanol at 20° C., while stirring. The mixture is subsequently stirred for 1 hour and is then concentrated in vacuo by distilling off the solvent. The residue is partitioned between methylene chloride and water. The organic phase is separated off, dried over sodium sulphate and concentrated in vacuo. 7 g (97.2% of theory) of 1-(4-allyloxyphenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol of melting point 85° C. are obtained.

후처리

  1. stirringThe mixture is subsequently stirred for 1 hour
  2. concentrationis then concentrated in vacuo
  3. distillationby distilling off the solvent
  4. customThe residue is partitioned between methylene chloride and water
  5. customThe organic phase is separated off
  6. dry with materialdried over sodium sulphate
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-bf3ac941a9f04771a1236503f1887025
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610996

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