Methylamine → 1-(benzo[b]thiophen-7-yl)-N-methylmethanamine

HRID 649004노트

반응식

HRID 649004 반응식
Br[CH2:2][C:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH3:12][NH2:13]>ClCCl.C(O)C>[S:9]1[CH:10]=[CH:11][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([CH2:2][NH:13][CH3:12])[C:8]1=2

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 107517617-(Bromomethyl)-1-benzothiophene

생성물 1

HCID 107024531-(benzo[b]thiophen-7-yl)-N-methylmethanamine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

7-Bromomethylbenzo[b]thiophene is dissolved in dichloromethane, added to 40 ml of a 33% solution of methylamine in ethanol and allowed to stand overnight. The resulting mixture is concentrated and the residue taken up in dichloromethane and extracted with 2N HCl. The aqueous phase is made strongly basic with NaOH and shaken with dichloromethane. The organic phase is dried with potassium carbonate, concentrated by evaporation and the residue vacuum distilled to produce the title product as an oil. B.p.=103°/1.3 mbar.

후처리

  1. concentrationThe resulting mixture is concentrated
  2. extractionextracted with 2N HCl
  3. dry with materialThe organic phase is dried with potassium carbonate
  4. concentrationconcentrated by evaporation
  5. distillationthe residue vacuum distilled

출처 및 근거

ORD 기록
ord-8aaa18b0b5a44412abfae50677459ff9
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737516

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