3-Bromo-7-methyl-1-benzothiophene → 3-Cyano-7-methylbenzo[b]thiophene

HRID 649013노트

반응식

HRID 649013 반응식
Br[C:2]1[C:3]2[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:4]=2[S:5][CH:6]=1.[C:12]([Cu])#[N:13]>N1C=CC=CC=1>[C:12]([C:2]1[C:3]2[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:4]=2[S:5][CH:6]=1)#[N:13]

참가 물질

4

반응물 2

HCID 6150893-Bromo-7-methyl-1-benzothiopheneHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 147804933-Cyano-7-methylbenzo[b]thiophene

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3 g of 3-bromo-7-methylbenzo[b]thiophene and 1.1 g CuCN are dissolved in dry pyridine and heated at 220° in an autoclave for 12 hours. The mixture is cooled, concentrated, the residue partitioned between dichloromethane and dilute HCl and the organic phase washed, dried and concentrated. Chromatography of the residue over silica gel (toluene) yields the title compound as pale-yellow crystals. M.p.=82°-84°.

후처리

  1. temperatureheated at 220° in an autoclave for 12 hours
  2. temperatureThe mixture is cooled
  3. concentrationconcentrated
  4. customthe residue partitioned between dichloromethane and dilute HCl
  5. washthe organic phase washed
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c90280854a7b4e6fafb5bea2ad624009
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737516

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