Tetrahydrofuran → HCID 20144491, 화합물

HRID 649017노트

반응식

HRID 649017 반응식
Br[C:2](Br)=[CH:3][C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=2[S:7][CH:8]=1.O1CCCC1.C([Li])CCC.C([O-])(O)=O.[Na+]>CCCCCC>[C:3]([C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=2[S:7][CH:8]=1)#[CH:2]

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 20144461HCID 20144461, 화합물HCID 178418339Butyllithium

생성물 1

HCID 20144491HCID 20144491, 화합물

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

0.6 g of 3-(dibromovinyl)-7-methylbenzo[b]thiophene are dissolved in abs. tetrahydrofuran and 3.38 ml of a 15% solution of n-butyllithium in n-hexane are added dropwise under inert gas and at -78°. Stirring is continued for one hour at -78° and the mixture subsequently warmed to room temperature, poured into saturated aq. NaHCO3 and extracted with ether. The organic phase is washed, dried, concentrated and directly further reacted.

후처리

  1. extractionextracted with ether
  2. washThe organic phase is washed
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0eb66eba03164279873631165f2d56a4
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737516

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