3-amino-N-ethylpiperidine → 1-Octadecylcarbamoyl-2-methyl-3-(1-ethylpiperidin-3-yl)carbamoylglycerol

HRID 649054노트

반응식

HRID 649054 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][CH3:9])[CH2:3]1.[CH2:10]([NH:28][C:29]([O:31][CH2:32][CH:33]([CH2:36][O:37][C:38](OC1C=CC=CC=1)=[O:39])[O:34][CH3:35])=[O:30])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>>[CH2:10]([NH:28][C:29]([O:31][CH2:32][CH:33]([CH2:36][O:37][C:38](=[O:39])[NH:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][CH3:9])[CH2:3]1)[O:34][CH3:35])=[O:30])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

참가 물질

3

반응물 2

HCID 980943-amino-N-ethylpiperidineHCID 151012011-Octadecylcarbamoyl-2-methyl-3-phenoxycarbonylglycerol

생성물 1

HCID 545651881-Octadecylcarbamoyl-2-methyl-3-(1-ethylpiperidin-3-yl)carbamoylglycerol

반응 조건

온도
60 °C

실험 절차

3-Amino-1-ethylpiperidine (1 ml) was added to 1.3 g of 1-octadecylcarbamoyl-2-methyl-3-phenoxycarbonylglycerol, and the reaction solution was heated at 60° C. for 1 hour and purified by silica gel chromatography [ethyl acetate-methanol (10:1)] to give 1.13 g of the objective compound as a milk-white solid.

후처리

  1. custompurified by silica gel chromatography [ethyl acetate-methanol (10:1)]

출처 및 근거

ORD 기록
ord-3b792889efa5414abf8653d562e04a37
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04737518

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