Methyl 6-amino-5-nitropyridine-3-carboxylate → Methyl 5,6-diaminopyridine-3-carboxylate

HRID 649179노트

반응식

HRID 649179 반응식
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1>CO.[C].[Pd]>[NH2:12][C:11]1[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

참가 물질

4

반응물 1

HCID 13768248Methyl 6-amino-5-nitropyridine-3-carboxylate

생성물 1

HCID 9920476Methyl 5,6-diaminopyridine-3-carboxylate

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

1 Gram of methyl 6-amino-5-nitronicotinate was dissolved in 10 ml of methanol. To this solution was added 0.1 g of 5%-palladium-carbon, then hydrogen gas was absorbed at room temperature under a normal pressure. The reaction was stopped when the stoichiometric amount of hydrogen was absorbed. The catalyst was removed from the reaction mixture by filtration, and the solvent was removed by evaporation. The residue thus obtained was recrystallized from ethanol to yield 0.8 g of methyl 5,6-diaminonicotinate in the form of yellow needle-like crystals. Melting point: 154°-155° C.

후처리

  1. customhydrogen gas was absorbed at room temperature under a normal pressure
  2. customwas absorbed
  3. customThe catalyst was removed from the reaction mixture by filtration
  4. customthe solvent was removed by evaporation
  5. customThe residue thus obtained
  6. customwas recrystallized from ethanol

출처 및 근거

ORD 기록
ord-0dd86a8cbda34bd3b0441db805319887
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04738970

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