Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Diphenylmethane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Butanoyl-1-trityl-imidazole | HCID 14736374 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | Diphenylmethane | HCID 7580 | 200% |
반응 단계
A solution of 4.30 g (25.8 mmols) of diphenylmethane in 50 ml of THF is prepared in inert atmosphere (nitrogen) then cooled in an ice bath. First 16.7 ml of butyllithium of a 1.7M solution in hexane and then, drop by drop, a solution of 4.90 g (12.9 mmols) of the previous ketone 3 in 50 ml of THF, are added slowly. The resultant mixture is stirred for 2 hours at room temperature and then 50 ml of a saturated aqueous solution of ammonium chloride and 100 ml of water are added. Extraction with ethyl acetate followed by evaporation of the previously dried extracts yields alcohol 4 which is recrystallised in cyclohexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04738979 |
| 출처 데이터셋 | uspto-grants-1988_04 |
| ORD ID | ord-706d9badff444c799cbd39809ca4d99a |
| 출처 메모 | uspto-grants-1988_04 |