Methanol → HCID 14809493, 화합물

HRID 649310노트

반응식

Cl[C:2]1([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[OH:22])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.[CH3:23][OH:24]>>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:2]1([O:24][CH3:23])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

참가 물질

반응물 2

HCID 887Methanol

HCID 14809492HCID 14809492, 화합물

생성물 1

HCID 14809493HCID 14809493, 화합물수율 85.3%

실험 절차

A mixture of 2-chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (14.0 g, compound No. 3) and methanol (200 ml) is stirred for 2 hours at room temperature, and the separated crystals are collected by filtration to give 11.8 g (85.3%) of the titled compound.

후처리

filtrationthe separated crystals are collected by filtration

출처 및 근거

ORD 기록: ord-8dc0d765e6054906b9896044b16b1db3
출처 데이터셋: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04739050

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