Methanethiol → HCID 14809494, 화합물

HRID 649311노트

반응식

HRID 649311 반응식
Cl[C:2]1([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[OH:22])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.[CH3:23][SH:24]>O1CCCC1>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:2]1([S:24][CH3:23])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

참가 물질

4

반응물 2

HCID 878MethanethiolHCID 14809492HCID 14809492, 화합물

생성물 1

HCID 14809494HCID 14809494, 화합물수율 78.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (12.3 g, compound No. 3) is added to a mixture of 30% aqueous methyl mercaptan solution (26 ml) and tetrahydrofuran (50 ml). The mixture is stirred for 1.5 hours at room temperature and concentrated in vacuo. The separated crystals are collected by filtration to give 10.0 g (78.3%) of the titled compound.

후처리

  1. concentrationconcentrated in vacuo
  2. filtrationThe separated crystals are collected by filtration

출처 및 근거

ORD 기록
ord-e7ac83adb3084309bbc6d48504431d6f
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04739050

반응 노트

불러오는 중…