1H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl- → HCID 178462747, 화합물

HRID 649493

반응식

HRID 649493 반응식
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N:6]([CH2:10][CH3:11])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.Cl[CH2:16][CH2:17][NH:18][S:19]([CH3:22])(=[O:21])=[O:20]>C1(OC)C=CC=CC=1>[Cl-:1].[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N+:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]([CH2:16][CH2:17][NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 767171H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl-HCID 89092N-(2-Chloroethyl)methanesulphonamide

생성물 1

HCID 178462747HCID 178462747, 화합물

시약·촉매·용매 1

HCID 7519Anisole용매

반응 조건

온도
150 °C

실험 절차

22.9 g (0.1 mol) of 5,6-dichloro-1-ethyl-2-methylbenzoimidazole and 23.6 g (0.15 mol) of N-(2-chloroethyl)methanesulfonamide were put into a 200-ml three-necked flask equipped with a stirrer and heated with stirring for 2 hours on an oil bath which had been heated to a temperature of 150° C. Then, 20 ml of anisole was added to the mixture. The mixture was then allowed to cool to room temperature with stirring. The resulting crystals were filtered off, washed with acetone and isopropanol, and dried.

후처리

  1. customequipped with a stirrer
  2. temperatureheated
  3. temperatureto cool to room temperature
  4. stirringwith stirring
  5. filtrationThe resulting crystals were filtered off
  6. washwashed with acetone and isopropanol
  7. customdried

출처 및 근거

ORD 기록
ord-a56c3e55fb414f519a9b494eeb94be17
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04740455

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