Anisole → HCID 178462746, 화합물

HRID 649498

반응식

HRID 649498 반응식
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N:6]([CH2:10][CH3:11])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.[Br:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[CH2:21][CH2:20][C:19]1=[O:24].C1(OC)C=CC=CC=1>C(OCC)(=O)C>[Br-:15].[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N+:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]([CH2:16][CH2:17][N:18]3[C:22](=[O:23])[CH2:21][CH2:20][C:19]3=[O:24])[C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 7519AnisoleHCID 767171H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl-HCID 135613951-(2-Bromoethyl)pyrrolidine-2,5-dione

생성물 1

HCID 178462746HCID 178462746, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
130 °C

실험 절차

11.5 g of 5,6-dichloro-1-ethyl-2-methylbenzoimidazole and 20.6 g of N-(2-bromoethyl)succinimide were put into a 200-ml three-necked flask equipped with a stirrer and a reflux condenser and heated for 2 hours on an oil bath which has been heated to a temperature of 130° C. 10 ml of anisole was added to the mixture. The admixture was then allowed to stand for cooling. 50 ml of ethyl acetate was added to the admixture. The admixture was then refluxed for 30 minutes. After being allowed to cool to room temperature, the resulting crystal was filtered off, washed with acetone, and then dried at a temperature of 50° C. for 5 hours. Yield: 18.7 g (86%).

후처리

  1. customequipped with a stirrer and a reflux condenser
  2. temperatureheated for 2 hours on an oil bath which
  3. temperaturefor cooling
  4. temperatureThe admixture was then refluxed for 30 minutes
  5. temperatureto cool to room temperature
  6. filtrationthe resulting crystal was filtered off
  7. washwashed with acetone
  8. customdried at a temperature of 50° C. for 5 hours

출처 및 근거

ORD 기록
ord-86e8fa36df7b4279be13c2ee187f9e9b
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04740455

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