참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Gamma-Valerolactone | HCID 7921 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ethyl 2-[(3,4-dichlorophenyl)amino]pyridine-3-carboxylate | HCID 20141561 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 생성물 | HCID 54717823 | HCID 54717823 | — |
반응 단계
A stirred mixture of gamma-valerolactone (40 g.), ethyl 2-(3,4-dichlorophenylamino)-nicotinate (20 g.) and potassium t-butoxide (30 g.) was warmed in an atmosphere of nitrogen to 110° C. and kept there for 5 hr. After cooling somewhat the product was poured into 1000 ml. of 5% KOH solution and was allowed to stir overnight. The basic solution was extracted with ether (2×500 ml.) and the aqueous solution was acidified to pH 5 with conc. HCl. The solid was filtered off, washed with water, dried in air then recrystallized from methanol/charcoal to yield the desired product, m.p. 232°-234° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04740511 |
|---|
| 출처 데이터셋 | uspto-grants-1988_04 |
|---|
| ORD ID | ord-4e261e8176814b56b37d4c9bd0933b4d |
|---|
| 출처 메모 | uspto-grants-1988_04 |
|---|
