Diethyl Ether → 12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine

HRID 64962노트

반응식

HRID 64962 반응식
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][C:6]1[CH:19]=[C:18]2[C:9]([NH:10][C:11]3[C:16]([S:17]2)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[C:8]2[CH:20]=[CH:21][CH:22]=[CH:23][C:7]=12.C(OCC)C>CN(C=O)C>[C:1]([N:10]1[C:9]2[C:18](=[CH:19][C:6]([OH:5])=[C:7]3[CH:23]=[CH:22][CH:21]=[CH:20][C:8]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6367Acetyl chlorideHCID 137124785-hydroxy-12H-benzo[a]phenothiazine

생성물 1

HCID 1371248512-acetyl-5-hydroxy-12H-benzo[a]phenothiazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Acetyl chloride (2 ml) was added to a solution of 5-hydroxy-12H-benzo[a]phenothiazine (1) (2.65 gm) in DMF (10 ml) and stirred for 30 minutes. Diethyl ether (100 ml) was added to the reaction mixture followed by ice-water (50 ml). The aqueous layer was decanted and the organic layer containing a solid was evaporated to dryness. The resulting residue was treated with acetone and filtered to afford the title compound.

후처리

  1. customThe aqueous layer was decanted
  2. additionthe organic layer containing a solid
  3. customwas evaporated to dryness
  4. additionThe resulting residue was treated with acetone
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-557d7981ff714096a9ff30da1c667084
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04611056

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