Ethanol → HCID 16775461, 화합물
반응식
[F:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=1[CH3:16])=[O:5].C1CCCCC=1.C(O)C>[Pd].O>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([NH:6][C:4](=[O:5])[C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]=2[F:1])=[C:8]([CH3:16])[CH:9]=1참가 물질
6
반응 조건
- 온도
- 4 °C
실험 절차
A mixture of 2-fluoro-N-(2-methyl-4-nitrophenyl)benzamide (4.55 g), cyclohexene (30 mL), ethanol (70 mL), water (30 mL) and 10% palladium on charcoal (3 g) is heated at reflux for 30 minutes. The mixture is filtered through diatomaceous earth and concentrated under reduced pressure. The resulting oil is dissolved in 50 mL of ethyl acetate and cooled at 4° C. for 12 hours. Filtration provides the product as a tan solid.
후처리
- temperatureis heated
- temperatureat reflux for 30 minutes
- filtrationThe mixture is filtered through diatomaceous earth
- concentrationconcentrated under reduced pressure
- dissolutionThe resulting oil is dissolved in 50 mL of ethyl acetate
- filtrationFiltration
출처 및 근거
- ORD 기록
- ord-c5810c0bc1a442c7b4ac0fbfc1168e90
- 출처 데이터셋
- uspto-grants-2001_08
- 특허 번호
- US06271236B1
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