Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 반응물 | Stannous cation | HCID 104883 | — |
| 반응물 | Ethyl 2-amino-6-methylbenzo[b]thiophene-3-carboxylate | HCID 18422153 | — |
| 반응물 | Ethyl 6-methyl-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422322 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate | HCID 18422261 | — |
반응 단계
In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-amino-6-methylbenzo[b]thiophene-3-carboxylate (4.18 g), 2-fluoronitrobenzene (2.5 g) and dimethyl sulfoxide (50 ml), crude crystals (7.5 g) of ethyl 6-methyl-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate were obtained. Without purification, in the same manner as in Starting Material Synthesis Example 21 and using ethanol (50 ml), 18% hydrochloric acid (70 ml) and tin(II) chlorihe.dihydrate (16 g), ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate (3.7 g) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06271225B1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-25e82fd7efdf443e972511b6509aa9e0 |
| 출처 메모 | uspto-grants-2001_08 |