2,4-Difluoronitrobenzene → HCID 18422344, 화합물

반응식

[NH2:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:13]#[N:14].F[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24]>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:4]2[C:3]([C:13]#[N:14])=[C:2]([NH:1][C:16]3[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=3[N+:23]([O-:25])=[O:24])[S:6][C:5]=2[CH:7]=1

참가 물질

반응물 2

HCID 679672,4-Difluoronitrobenzene

HCID 184222202-Amino-6-methoxy-1-benzothiophene-3-carbonitrile

생성물 1

HCID 18422344HCID 18422344, 화합물수율 29%

실험 절차

In the same manner as in Starting Material Synthesis Example 51 and using 2-amino-6-methoxybenzo[b]thiophene-3-carbonitrile (5.2 g) and 2,4-difluoro-nitrobenzene (4.0 g), 6-methoxy-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrile (2.5 g) was obtained.

후처리

customMaterial Synthesis Example 51

출처 및 근거

ORD 기록: ord-bfba4fd58f2f42a28127fd006ee151cf
출처 데이터셋: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06271225B1

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