Water → 2-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 650000노트

반응식

HRID 650000 반응식
[S:1]1[C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=[CH:2]1.[Br:16]Br.O>C(O)(=O)C>[Br:16][C:2]1[S:1][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 18422172Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one

생성물 1

HCID 184221932-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one수율 80.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one (2 g) was suspended in acetic acid (30 ml) and a solution of bromine (1.5 g) in acetic acid (10 ml) was added dropwise over 30 minutes. The mixture was stirred at room temperature for 35 minutes and poured into water. The precipitated crystals were collected by filtration and washed with water and diisopropyl ether to give 2-bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one (2.2 g).

후처리

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water and diisopropyl ether

출처 및 근거

ORD 기록
ord-9668b277fa4642cf9e29602a5f9122bf
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271225B1

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