Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropyl Ether → phenylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 2-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one | HCID 18422193 | — |
| 반응물 | Phenylborate | HCID 19793864 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Sodium Carbonate | HCID 10340 | — |
| 생성물 | phenylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one | HCID 18422186 | 83.8% |
반응 단계
2-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one (1.0 g) was dissolved in 2M sodium carbonate (8 ml)-toluene (8 ml)-ethanol (8 ml) and phenyl borate (620 mg) and tetrakstriphenylphosphine palladium (390 mg) were added. The mixture was stirred under reflux with heating for 80 minutes. The reaction system was cooled to room temperature and diisopropyl ether and ethyl acetate were added. The precipitated crystals were collected by filtration and the obtained crystals were washed with ethyl acetate and water to give phenylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (830 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06271225B1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-b04ddccd5c894e45a90bb6cdb81f3a2a |
| 출처 메모 | uspto-grants-2001_08 |