Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 8-(4'-Carboxymethyloxyphenyl)-1,3-dipropylxanthine 2-(biotinylamino)ethylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 8-(4-Carboxymethyloxy)phenyl-1,3-dipropylxanthine | HCID 126079 | — |
| 반응물 | N-Hydroxysuccinimido-d-biotin | HCID 129676281 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 8-(4'-Carboxymethyloxyphenyl)-1,3-dipropylxanthine 2-(biotinylamino)ethylamide | HCID 131714856 | — |
반응 단계
Compound 6d (24.1 mg, 0.056 mmol) was suspended in 1 ml DMF. N-Hydroxysuccinimido-d-biotin (Sigma, 23.6 mg, 0.069 mmol) was added with stirring. A solution formed after several minutes, and a precipitate appeared soon thereafter. After one day methanol (1 ml) and ether were added. The precipitate was collected and dried (yield 26.6 mg, 73%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04612315 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-eb793162060e4d608a6c1a06068b387a |
| 출처 메모 | uspto-grants-1986_09 |