(S)-(-)-1-Phenylethyl isocyanate → (S)-N-(2-hydroxy-4-nitrophenyl)-N'-(methyl benzyl)urea

HRID 650093노트

반응식

HRID 650093 반응식
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][C@H:13]([N:20]=[C:21]=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C@@H:13]([CH3:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:22]

참가 물질

3

반응물 2

HCID 2724173(S)-(-)-1-Phenylethyl isocyanateHCID 49847212-Amino-5-Nitrophenol

생성물 1

HCID 54257898(S)-N-(2-hydroxy-4-nitrophenyl)-N'-(methyl benzyl)urea수율 76.7%

실험 절차

(S)-N-(2-Hydroxy-4-nitrophenyl)-N′-(methylbenzyl)urea was prepared from 2-hydroxy 4-nitro aniline (308 mg, 2.0 mmol) and (S)-methyl benzyl isocyanate (2 mmol) according to the procedure in General Method A. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (462 mg, 76%). EI-MS m/z 300(M−H)−

후처리

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

출처 및 근거

ORD 기록
ord-e32df085c64f4fd0ad5a97cc515a9f74
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271261B1

반응 노트

불러오는 중…