Benzyl isocyanate → HCID 21714410, 화합물

HRID 650105노트

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HRID 650105 반응식
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:11][C:12]1[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14]>CN(C=O)C>[OH:11][C:12]1[C:18]([C:19]([F:20])([F:21])[F:22])=[CH:17][CH:16]=[CH:15][C:13]=1[NH:14][C:9]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10]

참가 물질

4

반응물 2

HCID 76639Benzyl isocyanateHCID 222727462-Amino-6-(trifluoromethyl)phenol

생성물 1

HCID 21714410HCID 21714410, 화합물수율 80.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
80 °C

실험 절차

To a solution of benzylisocyanate (74.56 mg, 0.56 mmol) in DMF (1.0 ml), 2-hydroxy-3-trifluoromethylaniline (100 mg, 0.56 mmol) was added. The reaction mixture was stirred at 80° C. for 16 hours. Chromatography of the resulting liquid on silica gel gave desired product (140 mg, 80%). EI-MS m/z 311.1 (M+).

출처 및 근거

ORD 기록
ord-c8ed9ed6e5624c16a62692ec914137eb
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271261B1

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