Trifluoroacetic acid → 2-Chloro-6-hydroxybenzonitrile

HRID 650106

반응식

HRID 650106 반응식
C([C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:10]=1[C:11]#[N:12])(=O)C1C=CC=CC=1.FC(F)(F)C(O)=[O:21]>C(Cl)Cl>[C:11]([C:10]1[C:13]([Cl:17])=[CH:14][CH:15]=[CH:16][C:9]=1[OH:21])#[N:12]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 21714411HCID 21714411, 화합물

생성물 1

HCID 44079952-Chloro-6-hydroxybenzonitrile수율 67%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2-Benzoyl-6-chlorobenzonitrile (10.0 g, 41 mmol) was dissolved in methylene chloride(40 ml) and trifluoroacetic acid(40 ml) and stirred at room temperature for 24 hrs. The reaction mixture is diluted with methylene chloride and extracted with water. The organic layer is dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4%MeOH/CHCl2) gave the desired product(4.2 g, 67%). 1H NMR (CD3COCD3): δ10.31 (s,1H), 7.51 (t, 1H), 7.11 (d, 1H) 7.05 (d, 1H).

후처리

  1. extractionextracted with water
  2. dry with materialThe organic layer is dried over MgSO4
  3. filtrationfiltered
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-6f65d7e8ef73451699026d5d6ab266c5
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271261B1

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