Sulfuric Acid → Isoamyl Cyanoacetate

HRID 650293노트

반응식

[C:1]([CH2:3][C:4]([O-:6])=[O:5])#[N:2].[CH2:7](O)[CH2:8][CH:9]([CH3:11])[CH3:10].S(=O)(=O)(O)O>>[C:1]([CH2:3][C:4]([O:6][CH2:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[O:5])#[N:2]

참가 물질

반응물 3

HCID 1118Sulfuric Acid

HCID 31260Isoamyl Alcohol

HCID 1551036Cyanoacetate

생성물 1

HCID 21714940Isoamyl Cyanoacetate

실험 절차

Using the procedure of Example 1, cyanoacetate acid (85.5 g; 1.00 mol) and isoamyl alcohol (176 g; 2 mol) are reacted in the presence of sulfuric acid (0.49 g; 0.005 mol). Isoamyl cyanoacetate (bp 133/20 mm of Hg) is recovered as a clear liquid. The yield was 150 g (97% of theoretical) and its purity was >99% (GC assay).

후처리

customIsoamyl cyanoacetate (bp 133/20 mm of Hg) is recovered as a clear liquid

출처 및 근거

ORD 기록: ord-85d371c307e6489fbdbfd936ddb8c73c
출처 데이터셋: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06271410B1

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