Water → 5-Methyloctahydro-1H-4,7-methanoinden-5-ol

HRID 650297

반응식

HRID 650297 반응식
[CH:1]12[CH2:11][CH:7]([C:8](=[O:10])[CH2:9]1)[CH:6]1[CH:2]2[CH2:3][CH2:4][CH2:5]1.[CH3:12][Mg]Cl.O>O1CCCC1>[CH3:12][C:8]1([OH:10])[CH2:9][CH:1]2[CH2:11][CH:7]1[CH:6]1[CH:2]2[CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 962Water2회HCID 965094,7-Methano-5H-inden-5-one, octahydro-HCID 178418332HCID 178418332, 화합물

생성물 1

HCID 134625055-Methyloctahydro-1H-4,7-methanoinden-5-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

Tricyclo [5.2.1.02,6] decan-8-one (15.0 g) in tetrahydrofuran (THF, 50 ml) is slowly added into CH3MgCl (9.7 g) in THF and the reaction mixture is stirred completely. Tetrahydrofuran (THF, 100 ml) with 5% of water is added into the reaction mixture. Then 100 ml of water is added to the reaction mixture. The reaction mixture is extracted by ether. The organic extract is concentrated in vacuo to yield 8-methyl-tricyclo [5.2.1.02,6] decan-8-ol (formula (X)) as white solid.

후처리

  1. extractionThe reaction mixture is extracted by ether
  2. extractionThe organic extract
  3. concentrationis concentrated in vacuo

출처 및 근거

ORD 기록
ord-ad544c725db040258fa7900dde80a2eb
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271412B1

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