Diethyl Ether → 2-Bromo-1-(5-indanyl)-2-(3-pyridyl)ethanone hydrobromide

HRID 65040

반응식

HRID 65040 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10](=[O:18])[CH2:11][C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[Br:19]Br.C(OCC)C>C(O)(=O)C.C(#N)C>[BrH:19].[Br:19][CH:11]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[C:10]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[CH2:1][CH2:2][CH2:3]2)=[O:18]

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 137146531-(5-Indanyl)-2-(3-pyridyl)ethanone

생성물 1

HCID 137146742-Bromo-1-(5-indanyl)-2-(3-pyridyl)ethanone hydrobromide수율 86%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6342Acetonitrile용매

실험 절차

In 20 ml of acetic acid was dissolved 4.3 g of 1-(5-indanyl)-2-(3-pyridyl)ethanone. To the solution was added 0.93 ml of bromine, which was stirred for one hour at 80°, then the reaction solution was cooled. Addition of 80 ml of ethylether gives a layer of oily substance. The supernatant was discorded, and the remainder was dissolved in 50 ml of acetonitrile. The solution was cooled to give 6.2 g of 2-bromo-1-(5-indanyl)-2-(3-pyridyl)ethanone hydrobromide, m.p. 176°-177° C. The yield was 86%.

후처리

  1. temperaturethe reaction solution was cooled
  2. customgives a layer of oily substance
  3. temperatureThe solution was cooled

출처 및 근거

ORD 기록
ord-e221fc28929e4cf7902d5a3a47bb4fa3
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04612321

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