참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid | HCID 2821908 | — |
| 생성물 | 3-Chloro-5-trifluoromethyl-pyridine-2-carbonyl chloride | HCID 22013555 | — |
반응 단계
89.3 g of 3-chloro-5-trifluoromethyl-2-pyridinecarboxylic acid (Example P3) are slowly heated to reflux with 60 ml of thionyl chloride and the mixture is then stirred at that temperature for 4 hours, after which it is cooled to 25° C. and concentrated to dryness in vacuo. Twice, toluene is added and the mixture is again concentrated to dryness. 94.0 g of the desired product are obtained in the form of a yellow residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06274536B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_08 |
|---|
| ORD ID | ord-ad87a9bcb6d84ff58a1cd54544b1e42f |
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| 출처 메모 | uspto-grants-2001_08 |
|---|
