[Cl:1][C:2]1[C:3]([C:9](=[O:11])[CH3:10])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.C([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])(=O)C.CCOCC.C([O-])C.[Na+]>C(O)C>[Cl:1][C:2]1[C:3]([C:9](=[O:11])[CH2:10][C:16]([C:17]([F:20])([F:19])[F:18])=[O:15])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=115.8 g of 3,5-dichloro-2-acetylpyridine are introduced together with 12.0 ml of trifluoroethyl acetate into 125 ml of absolute ether. With stirring, the mixture is cooled using an ice-bath and 46.6 ml of, a 21% sodium ethanolate solution in ethanol are added dropwise. The ice-bath is then removed and the mixture is subsequently stirred overnight at 25° C. After cooling the reaction mixture in an ice-bath and adding dropwise 7.5 ml of glacial acetic acid, the mixture is concentrated in vacuo. 39.0 g of 1-(3,5-dichloro-2-pyridyl)-3-trifluoromethylpropane-1,3-dione are obtained, which can be used directly for the following cyclisation step.
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